0
ARTICLE |

Creatine Phosphokinase Release as a Measure of Tourniquet Effect on Skeletal Muscle

David Chiu, MD; Hsueh Hwa Wang, MD; Marvin Richard Blumenthal, MD
Arch Surg. 1976;111(1):71-74. doi:10.1001/archsurg.1976.01360190073013.
Text Size: A A A
Published online

• In anesthetized dogs, a pneumatic tourniquet was applied to a hind limb for one, two, or three hours. Resultant ischemic damage to skeletal muscle was assessed by creatine phosphokinase (CPK) levels in the femoral venous blood of the experimental limb after the tourniquet was released. The CPK levels did not rise after release of one-hour occlusion in three experiments. The elevation of CPK values was demonstrated after occlusion for two hours in three of four experiments, and after occlusion of three hours in all four experiments. When a three-hour occlusion was interrupted for 15 minutes after each hour in three experiments, elevation of CPK levels was minimal or absent. Thus, skeletal muscle injury, as measured by the level of venous CPK elevation, becomes apparent after two to three hours of occlusion and can be prevented by short periods of recirculation.

(Arch Surg 111:71-74, 1976)

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();