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Article |

Deep Venous Thrombosis and Postsplenectomy Thrombocytosis

William W. Coon, MD; John Penner, MD; G. Patrick Clagett, MD; Nancy Eos
Arch Surg. 1978;113(4):429-431. doi:10.1001/archsurg.1978.01370160087014.
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• Eighty-six patients undergoing elective splenectomy have been investigated preoperatively and postoperatively by serial platelet counts and leg scanning using iodine 125-labeled fibrinogen. The presence of deep leg vein thromboses detected by labeled fibrinogen was confirmed by dye phlebography. In only five patients (6%) did deep venous thrombosis develop. In none of these five patients did an elevation in platelet count to 600,000/cu mm develop before or at the time of development of the thrombosis. None of 21 other patients who did have a rise in platelet count greater than 1,000,000/cu mm had evidence of venous thrombosis. These data do not substantiate the need for routine prophylactic antithrombotic therapy in patients in whom postsplenectomy thrombocytosis develops.

(Arch Surg 113:429-431, 1978)


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