• The study concerns the effect of angiotensin II when infused into the systemic and portal blood flow on the general and renal hemodynamics in normal dogs and in hypertensive dogs, as well as the effect of the operation of portacaval transposition (PCT) on the course of renovascular hypertension. When peptide is infused at a rate that causes a moderate pressor effect into the systemic blood flow of normal dogs, an antidiuretic and antinatriuretic effect is obtained, whereas in hypertensive dogs an increase of diuresis, natriuresis, and a less distinct pressor effect are obtained. When angiotensin II is infused into the portal flow, a less distinct pressor and renal effect is seen in dogs with renovascular hypertension. The operation of PCT of the vessels results in a hypotensive effect in the dogs with renovascular hypertension.
(Arch Surg 114:216-220, 1979)