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Gastric Tissue Prostaglandin Levels Effect of Vagotomy

Stephen Creaghe, MD; Gerald Peskin, MD; A. Gerson Greenburg, MD, PhD; Richard P. Saik, MD
Arch Surg. 1979;114(3):331-332. doi:10.1001/archsurg.1979.01370270101019.
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• To determine tissue prostaglandin levels in antrum and fundus and to examine the effect of vagotomy and distention on tissue prostaglandin levels, truncal and parietal cell vagotomies were performed on rats that were killed at 2, 4, and 6 weeks postoperatively with antral and fundic prostaglandin E1 levels being determined. The fundus has considerably higher levels of prostaglandin than the antrum. No differences after any type of vagotomy however, were noted. It cannot be concluded from this study that increased prostaglandin levels result from vagotomy.

(Arch Surg 114:331-332, 1979)


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