0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Splenic Regeneration-Reply

RALPH S. GRECO, MD
Arch Surg. 1980;115(11):1401-1402. doi:10.1001/archsurg.1980.01380110133023.
Text Size: A A A
Published online

In Reply.—The data presented by Scher and Coil lend further support to the now well-documented ability of the spleen to regenerate after partial splenectomy. Different rates of regeneration may well be explained by species differences and are far less important than their demonstration that these remnants protect animals against pneumococcal challenge. Indeed, more recent experiments from our laboratory show that both hilar and short gastric remnants weighing less than 25% of the spleen's original mass will regenerate and protect recipients against subsequent pneumococcal bacteremia.1 There is no reason to presume that even smaller splenic remnants will not do the same. These data appear to support splenic salvage even after severe injuries provided a small amount of splenic tissue remains attached to identifiable blood vessels. The role of the spleen in protection against pneumococcal sepsis appears to be related to its filtering effect rather than to immunologic functions.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();