Nonantral Gastric Carcinoids and Hypergastrinemia

Arch Surg. 1981;116(9):1238. doi:10.1001/archsurg.1981.01380210100021.
Text Size: A A A
Published online

To the Editor.—Abrams reported in the Archives (1980;115:1219-1221) a case of multiple malignant carcinoids of the stomach successfully treated with total gastrectomy. The patient also showed pronounced hypergastrinemia and diffuse hyperplasia of argyrophil cells in the nonantral mucosa of the stomach. Since gastrinsecreting cells of the stomach are strictly confined to the antropyloric region, neither tumor cells nor hyperplastic cells can be expected to represent the source of the patient's hypergastrinemia. However, all evidence indicates that the carcinoids are composed of the so-called enterochromaffin-like (ECL) cells, the most frequent (though functionally unknown) endocrine cell type in the nonantral portion of the stomach.1,2

In the study of a case of ECL cell carcinoid and hyperplasia associated with long-standing gastrojejunostomy,1 my colleagues and I suggested that concomitant high levels of gastrin may stimulate the growth of ECL-cell carcinoids. The hypothesis was based on the following evidence. Gastrin is known


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.