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Nonspecific Enhancement of Resistance to Local Bacterial Infection in Starved Mice

Robert B. Galland, MB, FRCS; Laura S. Trachtenberg, MA; Nancy Rynerson; Hiram C. Polk Jr, MD
Arch Surg. 1982;117(2):161-164. doi:10.1001/archsurg.1982.01380260041007.
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• We studied the effect of muramyl dipeptide (MDP) on enhancing resistance to local bacterial challenge in starved mice. The challenge consisted of the intramuscular insertion of a suture laden with Klebsiella pneumoniae. Mice that had been pretreated with MDP had a statistically lower rate of bacterial recovery at the site of the challenge, had consistently fewer bacteria in the blood, and had improved short-term survival. By enhancing local bacterial containment, MDP pretreatment of immunocompromised animals reduces the level of bacteremia and subsequent mortality.

(Arch Surg 1982;117:161-164)

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