We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Use of Crystalline Hemoglobin as Replacement of RBC Mass

Carl J. Hauser, MD; Cary Kaufman, MD; Robert Frantz, MD; Clay Shippy, MS; Sandra Schwartz, MS; William C. Shoemaker, MD
Arch Surg. 1982;117(6):782-786. doi:10.1001/archsurg.1982.01380300030008.
Text Size: A A A
Published online


• Replacement of a circulatory RBC mass was performed isovolemically in experimental dogs using either 7% crystalline hemoglobin solution with a low P50 (the oxygen tension necessary to produce 50% saturation of hemoglobin at pH 7.4 and 37 °C) or with an albumin solution. Progressive RBC depletion caused increased cardiac output in both groups. Oxygen delivery was better preserved after using the crystalline hemoglobin solution, and, under conditions of extreme anemia, oxygen transport using this solution enabled dogs to survive the otherwise lethal insult. Although administration of crystalline hemoglobin preserved oxygen transport, oxygen off-loading was at a lower tension because of the lower P50. Decreased mixed venous oxygen tension, which presumably reflects lower tissue oxygen tension, was associated with systemic vasoconstriction. The administration of oxygen-carrying solutions with low P50 values results in a relatively vasoconstricted state. This vascular response is mediated by changes in tissue oxygen tension, rather than by impaired tissue oxygen consumption.

(Arch Surg 1982;117:782-786)


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.