0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Studies on Segmental Pancreatic Autotransplants in Dogs

Rino Munda, MD; Yacov Berlatzky, MD; Majvi Jonung, MD; Richard F. Murphy, PhD; Kim Brackett, PhD; Stephen N. Joffe, MD; J. Wesley Alexander, MD, ScD
Arch Surg. 1983;118(11):1310-1315. doi:10.1001/archsurg.1983.01390110058013.
Text Size: A A A
Published online

• Success with segmental pancreas transplants has been impaired by immunologic and technical considerations. Experiments were performed with autotransplants to avoid immunologic problems, allowing concentration on surgical techniques. Survival of splenic lobe pancreas autotransplants in pancreatectomized dogs was extended with relocation of the graft from the groin to the abdominal cavity and distal arteriovenous fistula to increase graft flow. Fibrosis of the graft occurred regardless of the method of duct treatment, latex (Neoprene) or Silastic injection or free intraperitoneal drainage. Hormonal responses in normoglycemic animals showed normal insulin levels (6±0.8 μU/mL) as compared with controls (5.4±0.9 μU/mL), while peak levels during arginine stimulation were higher in dogs with autotransplants (39.7±20 μU/mL) than in controls (15.1 ±1.9 μU/mL) Pancreatic polypeptide basal levels in animals with transplants were 42± 2.2 pg/mL as compared with 256 ± 28 pg/mL in controls, with no response to bombesin or protein meal stimulation. In this model, splenic lobe was capable of maintaining normoglycemia with avoidance of ketogenic amino acid patterns. Continuous fibrosis was the biggest threat to islet survival.

(Arch Surg 1983;118:1310-1315)

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();