0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Duodenal Adenoma With Atypia Following Oral Administration of Tegafur

YOSHIAKI JOHJIMA, MD; TETSUO IMAMURA, MD; RYO SHIMAZU, MD; OSAMU IHARA, MD; TAKESHI OOHARA, MD; TOSHIKAZU MURAKAMI, MD; YOSHIO KONDO, MD
Arch Surg. 1983;118(12):1454. doi:10.1001/archsurg.1983.01390120074030.
Text Size: A A A
Published online

To the Editor.—Since chemotherapy for treating malignant neoplasms has been more frequently adopted in recent years, secondary development of malignant tumors possibly induced by chemotherapeutic agents has become a serious problem. We report a case of duodenal adenoma with atypia, which seemed to be associated with administration of tegafur (1-[2-tetrahydrofuryl]-5-fluorouracil).

Report of a Case.—A 48-year-old man, who had undergone a gastrectomy with lymph node dissection for gastric carcinoma at 43 years of age, received tegafur in a dosage of 600 mg/day, for a total of 789 g during four years eight months. He was subsequently found to have a sessile tumor, about 1.5 cm in longest axis, in the second portion of the duodenum, 4 cm distal to the papilla. The histologic findings shown by resection were interpreted as an adenoma with atypia.

Comment.—Primary carcinoma and adenoma of the duodenum are extremely rare.1 The series of

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

* * SCHEDULED MAINTENANCE * *

Our websites may be periodically unavailable between midnight and 04:00 ET Thursday, July 10th, for regularly scheduled maintenance.

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();