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Increased Susceptibility to Infection Related to Extent of Burn Injury

Roger W. Yurt, MD; Albert T. McManus, PhD; Arthur D. Mason Jr, MD; Basil A. Pruitt Jr, MC, USA
Arch Surg. 1984;119(2):183-188. doi:10.1001/archsurg.1984.01390140047008.
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• A model of burn wound sepsis in which the mortality caused by infection was significantly greater after a 60% total body surface area (TBSA) burn than after a 30% TBSA burn was developed in the rat. In rats that sustained a 60% TBSA burn (30% partial plus 30% full thickness), the 30% TBSA partial-thickness burn that was inoculated with Pseudomonas aeruginosa strain 59-1244 developed invasive wound infection (>105 colony-forming units per gram of tissue). Infection did not develop in rats that had a 30% TBSA partial-thickness burn inoculated, without additional injury. The additional burn in the rats with a 60% TBSA burn seemed to affect the development of infection in the partial-thickness wound and the overall outcome by a mechanism other than by infection of the full-thickness wound itself. Autopsy confirmed that mortality was caused by sepsis.

(Arch Surg 1984;119:183-188)


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