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Systemic Prophylactic Antibiotics in Elective Biliary Surgery

Zvi Kaufman, MD; Moshe Engelberg, MD; Avinoam Eliashiv, MD; Raphael Reiss, MD
Arch Surg. 1984;119(9):1002-1004. doi:10.1001/archsurg.1984.01390210006002.
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• We tested the effectiveness of prophylactic antibiotics in elective cholecystectomy in 105 patients in a single-blind, controlled randomized trial. Fifty-six patients received prophylactic antibiotics and 49 patients entered the control group. Of the patients who received prophylactic antibiotics, 3.6% had wound infections, v 24.5% in the control group. The rate of wound infection in patients with positive bile cultures, diabetes, appendectomies, and choledochotomies was 24.4%, v 3.4% in the group who had cholecystectomies only, with negative bile cultures and no diabetes. We concluded that prophylactic antibiotics are effective in patients with high-risk factors such as diabetes mellitus, exploration of the choledochus, and appendectomy, and in patients with positive bile cultures.

(Arch Surg 1984;119:1002-1004)


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