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Article |

The Application of Antibiotic Bonding to the Treatment of Established Vascular Prosthetic Infection

Ralph S. Greco, MD; Stanley Z. Trooskin, MD; Anthony P. Donetz; Richard A. Harvey, PhD
Arch Surg. 1985;120(1):71-75. doi:10.1001/archsurg.1985.01390250063010.
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• We used surfactant-mediated antibiotic bonding to treat established vascular prosthetic infections in an animal model. The infrarenal aorta of dogs was replaced with a polytef (PTFE) graft locally contaminated with Staphylococcus aureus. Infected grafts were then replaced with control polytef or polytef bonded with benzylkonium chloride and penicillin G tagged with radioactive carbon, or polytef bonded with tridodecylmethylammonium chloride and penicillin G tagged with radioactive carbon. Both types of antibiotic-bonded grafts had significantly fewer infections than control grafts did. The labeled penicillin G remained bound to both groups of antibiotic-bonded grafts for at least three weeks. In a second group of studies, surfactant-treated polytef adsorbed parenterally administered labeled penicillin G in highly significant concentrations compared with control grafts. These studies suggest the possibility that human vascular prosthetic infection may be treated with an antibiotic-bonded graft.

(Arch Surg 1985;120:71-75)


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