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Relation of Free Silicone to Human Breast Carcinoma

Leon Morgenstern, MD; Stewart H. Gleischman, MD; Stephen L. Michel, MD; James E. Rosenberg; Irving Knight, MD; David Goodman, MD
Arch Surg. 1985;120(5):573-577. doi:10.1001/archsurg.1985.01390290051008.
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• Of 12 women with carcinoma of the breast and coexistent silicone mastopathy, nine had had injections of liquid silicone for breast augmentation; three had leaking silicone-gel prostheses. The clinical findings indicated that early diagnosis was obscured by the silicone-induced mastopathy, which rendered the interpretation of physical findings and mammograms difficult. The pathologic findings were suggestive of a possible adverse effect of the presence of free silicone within the breast tissue, axillary nodes, and axillary fat. Although no causal relationship between silicone and breast carcinoma is implied, a heightened awareness of the possible coexistence of silicone mastopathy and breast carcinoma is necessary.

(Arch Surg 1985;120:573-577)


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