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The Effect of Vitamin E on Experimentally Induced Peritoneal Adhesions in Mice

Peter Kagoma, MD; Steven N. Burger, MD; Eli Seifter, PhD; Stanley M. Levenson, MD; Achilles A. Demetriou, MD, PhD
Arch Surg. 1985;120(8):949-951. doi:10.1001/archsurg.1985.01390320073015.
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• Previous studies in our laboratory demonstrated that dietary supplementation with vitamin A enhances peritoneal adhesion formation in mice. Other researchers have shown that vitamin E antagonizes some effects of vitamin A in various systems, eg, wound healing. We investigated our hypothesis that dietary supplementation with vitamin E would decrease peritoneal adhesion formation. Adult mice were divided into the following groups: group 1, which ate a standard chow containing 65 IU of vitamin E per kilogram diet (twice the National Research Council's recommended daily allowance for normal mice); and group 2, which ate the same chow supplemented with vitamin E at 300 IU/kg diet (a nontoxic level). Following peritoneal ligation, all mice were killed on the tenth postoperative day and their peritoneal cavities examined for the presence and extent of adhesions. There was a statistically significant decrease in the incidence and degree of adhesions in the vitamin E—supplemented animals; these data supported our hypothesis.

(Arch Surg 1985;120:949-951)

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