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Development of a Safe and Effective One-Minute Preoperative Skin Preparation

J. Wesley Alexander, MD, ScD; Sandy Aerni, RN; James P. Plettner, MD
Arch Surg. 1985;120(12):1357-1361. doi:10.1001/archsurg.1985.01390360023006.
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• Three consecutive controlled randomized clinical trials utilizing 1,324 patients were conducted to study the efficacy of incise drapes to prevent wound infections. When a polyester antimicrobial incise drape (loban 2 Antimicrobial Film) was applied to an operative area after a one-minute skin preparation using either 70% alcohol or 2% iodine in 90% alcohol, the clean wound infection rate (1.3%) and overall wound infection rate (2.5%) were comparable to those following a standard ten-minute skin preparation with Betadine (1.3% and 2.3%, respectively). During preliminary studies, it was demonstrated that separation of polyethylene antimicrobial incise drapes from the skin during operation was associated with a sixfold increase in infection rate when compared with operations in which the incise drape did not lift. Design of the drape and technique of application are important considerations in preventing lift from the skin.

(Arch Surg 1985;120:1357-1361)


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