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Antithrombin, Prekallikrein, and Fibronectin Levels in Surgical Patients

Robert F. Wilson, MD; Eberhard F. Mammen, MD; Martin C. Robson, MD; John P. Heggers, PhD; George Soullier; Patricia A. DePoli
Arch Surg. 1986;121(6):635-640. doi:10.1001/archsurg.1986.01400060029002.
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• Antithrombin (AT), prekallikrein (PK), and fibronectin (FN) levels were measured in the plasma of 290 patients. The mean (± SD) lowest AT level measured in 287 patients was 70% ± 18% (normal, 75% to 120% of control). The mean lowest AT level in 81 septic patients (49% ± 17%) was significantly lower than in the 206 patients without sepsis (78% ± 22%). The mean AT level in 60 patients who died (42% ± 22%) was significantly lower than in 227 patients who lived (78% ± 19%). The mean lowest PK level measured in 71 patients was 42% ± 17% (normal, 80% to 120%). The mean PK level in 32 septic patients (26% ± 12%) was significantly lower than in 39 patients who were not septic (54% ± 19%). The mean lowest FN level measured in 45 patients was 193 ± 86 μg/mL (normal, 160 to 240 μg/mL). The mean FN level in 15 septic patients (128 ± 72 μg/mL) was significantly lower than in the 30 nonseptic patients (266± 84 μg/mL). Following AT, PK, and FN levels in critically ill surgical patients may allow earlier diagnosis and more effective treatment of sepsis.

(Arch Surg 1986;121:635-640)


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