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Acid and Gastrin Levels Following Pyloric-Preserving Pancreaticoduodenectomy

Nathan W. Pearlman, MD; Gregory V. Stiegmann, MD; Dennis J. Ahnen, MD; Arnold L. Schultz, PhD; Louis M. Fink, MD
Arch Surg. 1986;121(6):661-664. doi:10.1001/archsurg.1986.01400060055006.
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• Acid and gastrin production after pyloric-preserving pancreaticoduodenectomy was evaluated in six patients. Five patients had low-normal basal and stimulated acid output; the sixth patient was achlorhydric. Fasting gastrin levels were less than 90 to 105 pg/mL (normal range) in five patients, three of whom had stimulated gastrin levels that remained below this range. Two patients had stimulated gastrin levels of 510 pg/mL and 205 pg/mL, respectively, within 15 minutes of eating; however, both levels returned to normal by 120 minutes' time. The sixth patient had mildly elevated fasting (105 pg/mL) and stimulated gastrin levels (160 to 200 pg/mL) throughout the test period. The results suggest that pyloric-preserving pancreaticoduodenectomy does not lead to either gastric hyperacidity or persistent hypergastrinemia.

(Arch Surg 1986;121:661-664)


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