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Advances in Drug Therapy for Peptic Ulcer Disease

Theodore N. Pappas, MD; Sean J. Mulvihill, MD; Yositi Goto, PhD; Haile T. Debas, MD
Arch Surg. 1987;122(4):447-450. doi:10.1001/archsurg.1987.01400160073011.
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• Recently, three new drug types have emerged to treat peptic ulceration. We compared the mechanism of action of omeprazole and somatostatin-14, both inhibitors of gastric acid, with that of tetraprenylacetone, a drug thought to be cytoprotective in the upper gut. Omeprazole and somatostatin-14 caused potent inhibition of meal-stimulated acid secretion in the dog (92% ± 6% and 97% ±1%, respectively). On the other hand, tetraprenylacetone had no significant inhibitory effect on acid secretion (4%±17%). In separate studies, tetraprenylacetone was shown to be a stimulant of gastric bicarbonate secretion in the rabbit, increasing bicarbonate secretion from a basal level of 0 to 86±28 pmol/2 h. Tetraprenylacetone was also found to be a strong stimulant of canine pancreatic bicarbonate secretion. The ability of tetraprenylacetone to stimulate endogenous bicarbonate secretion may explain its ability to heal ulcers both experimentally and clinically.

(Arch Surg 1987;122:447-450)


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