November 1987, Vol 122, No. 11 >

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ARTICLE | November 1987

Therapy of Peritoneal Carcinomatosis of Human Colon Cancer Xenografts With Yttrium 90—Labeled Anti—Carcinoembryonic Antigen Antibody ZCE025

David M. Hyams, MD; Jose M. Esteban, MD; Charles P. Lollo, PhD; Barbara G. Beatty, PhD; J. David Beatty, MD

Arch Surg. 1987;122(11):1333-1337. doi:10.1001/archsurg.1987.01400230121021.

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• The present study was undertaken to determine whether an anti—carcinoembryonic antigen (CEA) monoclonal antibody (MAB), labeled with the potent beta emitter yttrium 90, could alter the growth of diffuse intraperitoneal carcinomatosis of colon cancer. Nude mice bearing the CEA-producing human tumor line LS174T received therapy with the anti-CEA MAB ZCE025 ⁹⁰Y. Animals were evaluated 12 days after therapy. Untreated animals had a mean (±SEM) tumor burden of 3.99±0.10 g, while animals treated with ZCE025 ⁹⁰Y had 0.29±0.04 g present. This decrease was significant compared with the 1.31 ±0.16 g of tumor present in animals treated with a ⁹⁰Y-labeled nonspecific antibody 96.5c. The therapeutic effects seen with ZCE025 ⁹⁰Y suggest a potentially useful role for ⁹⁰Y-labeled anti-CEA MABs in the treatment of gastrointestinal carcinomatosis.

(Arch Surg 1987;122:1333-1337)

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Hyams DM, Esteban JM, Lollo CP, Beatty BG, Beatty J. Therapy of Peritoneal Carcinomatosis of Human Colon Cancer Xenografts With Yttrium 90—Labeled Anti—Carcinoembryonic Antigen Antibody ZCE025. Arch Surg. 1987;122(11):1333-1337. doi:10.1001/archsurg.1987.01400230121021.

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Therapy of Peritoneal Carcinomatosis of Human Colon Cancer Xenografts With Yttrium 90—Labeled Anti—Carcinoembryonic Antigen Antibody ZCE025

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