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Generation of an Anti—Interleukin 2 Factor in Healing Wounds

Robert J. Breslin, MD; Adrian Barbul, MD; Thomas S. Kupper, MD; John P. Knud-Hansen, MD; Hannah L. Wasserkrug; Gershon Efron, MD
Arch Surg. 1988;123(3):305-308. doi:10.1001/archsurg.1988.01400270039005.
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• Previously we have noted that fluid obtained from ten-day-old healing wounds noncytotoxically inhibits the blastogenesis of lymphocytes in response to mitogens or antigens. Since these lymphocytic responses are interleukin 2 (IL-2)—mediated, we looked for a specific IL-2 inhibitor in wound fluid. We have found that wound fluid blocks the response of thymic lymphocytes and of two cloned T-helper cell lines (D10 and HT2) to exogenous human recombinant IL-2. The wound fluid enhances fibroblast proliferation, thus demonstrating that its proliferative inhibitory activity is specific for lymphocytes. The findings suggest that wound fluid contains a factor that impairs lymphocyte response to IL-2, probably at the receptor or postreceptor level.

(Arch Surg 1988;123:305-308)


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