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Natural Killer Cells and the Guy's Hospital Trials-Reply

Arch Surg. 1988;123(7):914. doi:10.1001/archsurg.1988.01400310127030.
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In Reply.—Dr Evans suggests that cancer patients with low levels of NK cytotoxicity have developed distant metastases (presumably undetected) at the time of their original surgery. Although his comments refer to malignant lesions of the breast, this very attractive hypothesis can be tested to some extent in patients with colorectal cancer by reexamining the data from our original study. According to his hypothesis, patients presenting with low NK cytotoxicity are at increased risk of distant recurrence, but not of local recurrence, compared with patients with normal levels. Indeed, the risk of distant recurrence was 21% among patients with low preoperative NK cytotoxicity (<20% at effectortarget ratios of 17:1, for example), compared with 10% among patients with higher levels. The risks of local recurrence were 6% and 5%, respectively, among patients with low and high NK cytotoxicity. However, mean preoperative NK cytotoxicity was lower in patients who developed local recurrences


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