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ARTICLE |

Local Control in Rectal Cancer:  A Clinical Review and Meta-Analysis

Patrick Twomey, MD; Mary Burchell, MD; Dale Strawn, MD; James Guernsey, MD
Arch Surg. 1989;124(10):1174-1179. doi:10.1001/archsurg.1989.01410100076013.
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• We reviewed the factors influencing local control of potentially curable rectal cancer in 106 patients. There was improvement in stage-adjusted local control associated with increasing use of adjuvant radiation therapy. A meta-analysis of the English-language literature through 1988 also supported the effectiveness of adjuvant radiation therapy in all but the lowest-risk patients. No effect on survival was identified in either analysis, but a reduction of up to 40% in local recurrence rates may be achieved with doses of 3000 cGy or more.

(Arch Surg. 1989;124:1174-1179)

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