Protein Differences in Human Pancreatic Cancer Cell Lines With Diverse Metastatic Potential

Michael A. Schwalke, MD; Craig M. Doremus, MS; Ronald Bleday, MD; Harold J. Wanebo, MD; Michael P. Vezeridis, MD
Arch Surg. 1990;125(4):469-471. doi:10.1001/archsurg.1990.01410160055012.
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• High-resolution two-dimensional polyacrylamide gel electrophoresis was performed on the pancreatic cell lines SG, SG-R, FG, and L3.5, which when injected into the spleen of nude mice produced hepatic metastases in 0%, 20%, 64%, and 100% of the animals, respectively. A total of 981 proteins were quantitatively identified. In the highly metastatic lines, 13 proteins were present in statistically significant greater quantities, while 4 proteins were present in statistically significant greater quantities in the cell lines with a low metastatic potential. Two proteins were unique to the highly metastatic lines, while 16 proteins were unique to the lines with a low metastatic potential. These results suggest that there are considerable quantitative and qualitative differences in the cellular proteins of human pancreatic cancer cell lines with a varying metastatic potential and imply a biochemical basis to tumor heterogeneity and metastases.

(Arch Surg. 1990;125:469-471)


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