• The surgical sciences have made significant advances in our understanding of the immunological alterations associated with transplantation, trauma, oncology, and wound healing. Immune surveillance, regulation, and effector cell functions have been demonstrated to play integral roles in these disease states. Immune manipulation may be an effective therapeutic modality with even greater potential for the future. This study highlights recent progress in our understanding of immunomodulatory interventions that exploit manipulations in lymphocyte function in transplantation.
(Arch Surg. 1990;125:665-667)