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ARTICLE |

Radioimmune Localization of Occult Carcinoma

Rosemary B. Duda, MD; A. Michael Zimmer, PhD; Steven T. Rosen, MD; Katherine A. Gilyon, RN; Stewart Spies, MD; William Spies, MD; Bruce Merchant, MD, PhD
Arch Surg. 1990;125(7):866-870. doi:10.1001/archsurg.1990.01410190064010.
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• Patients with a rising serum carcinoembryonic antigen level and no clinical or roentgenographic evidence of recurrent or metastatic cancer present a treatment dilemma. Eleven such patients, 10 with a previously treated colorectal carcinoma and 1 with a previously treated breast carcinoma, received an injection of the anticarcinoembryonic antigen monoclonal antibody ZCE-025 labeled with the radioisotope indium 111. Nuclear scintigraphy was performed on days 3 and 5 through 7 to detect potential sites of tumor recurrence. The monoclonal antibody scan accurately predicted the presence or absence of occult malignancy in 7 (64%) patients. Second-look laparotomy confirmed the monoclonal antibody scan results in the patients with colorectal cancer, and magnetic resonance imaging confirmed metastatic breast cancer. This study demonstrates that In-ZCE-025 can localize occult carcinoma and may assist the surgeon in facilitating the operative exploration. In-ZCE-025 assisted in the initiation of adjuvant therapy for the patient with breast cancer.

(Arch Surg. 1990;125:866-870)

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