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The Importance of DNA Flow Cytometry in Node-Negative Breast Cancer

David J. Winchester, MD; Rosemary B. Duda, MD; Carey Z. August, MD; Robert A. Goldschmidt, MD; Debra M. Wruck, RN; Alfred W. Rademaker, PhD; David P. Winchester, MD; Douglas E. Merkel, MD
Arch Surg. 1990;125(7):886-889. doi:10.1001/archsurg.1990.01410190084013.
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• DNA flow cytometric analysis and conventional clinical factors were compared with disease outcome in 257 patients with node-negative infiltrating ductal carcinoma who had been treated between 1976 and 1983. Median follow-up was 80 months; none of the patients received adjuvant therapy. The relative prognostic importance of clinical variables, ploidy, and S-phase fraction was analyzed by Cox multivariate analysis. Ploidy was analyzable for 198 tumors and did not predict survival. Nuclear grade predicted disease-free survival for all patients. For 71 patients with diploid tumors, only high S-phase had a statistically significant association with relapse. For 127 patients with aneuploid tumors, tumor diameter predicted both disease-free survival and cancer death; histologic grade was also significant for predicting disease-free survival. In conclusion, flow cytometric determination of ploidy and S-phase fraction can provide valuable predictive information in node-negative breast cancer in addition to conventional variables.

(Arch Surg. 1990;125:886-889)


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