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The Effect of Interleukin 1α on Survival in a Murine Model of Burn Wound Sepsis

Geoffrey M. Silver, MD; Richard L. Gamelli, MD; Michael O'Reilly, MS; James C. Hebert, MD
Arch Surg. 1990;125(7):922-925. doi:10.1001/archsurg.1990.01410190120020.
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• We examined the effects of human recombinant interleukin 1α (IL-1 α) in a murine model of burn wound sepsis. The BDF1 male mice received a 15% burn injury, followed by burn wound inoculation with Pseudomonas aeruginosa. Improvement in survival was noted in the mice that received a single injection of 100 or 1000 ng of IL-1α in comparison with the control animals (IL-1α, 100 ng vs control, 60% vs 13%; IL-1α, 1000 ng vs control, 40% vs 0%). The animals that received 1 ng twice daily for 7 days had improved survival in comparison with the controls (IL-1α vs control, 70.8% vs 20.8%). The animals that received a single injection of 1000 ng after a bacterial challenge with 104P aeruginosa of IL-1α had fewer positive blood cultures at 48 hours compared with the controls (57% vs 89%). In addition, the animals that received 100 ng of IL-1α had significantly increased absolute neutrophil counts at 6, 24, and 48 hours after thermal injury and bacterial challenge with 103 colony-forming units of P aeruginosa. The use of cytokines to modulate the host response to injury or infection may lead to additional strategies to improve the outcome following burn injury.

(Arch Surg. 1990;125:922-925)

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