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Hydroxyethyl Starch Macromolecules Reduce Myocardial Reperfusion Injury

Bashir A. Zikria, MD; Chivukula Subbarao, MD; Mehmet C. Oz, MD; Sulli J. Popilkis, DVM; Ranjit Sachdev, MD; Prem Chauhan, MD; Harold P. Freeman, MD; Thomas C. King, MD
Arch Surg. 1990;125(7):930-934. doi:10.1001/archsurg.1990.01410190128022.
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• We assessed the value of a fraction of hydroxyethyl starch (HES Pz) in reducing the myocardial reperfusion injury in a canine open-chest model in which 1 hour of left anterior descending coronary artery occlusion was followed by 24 hours of reperfusion. Three treatment infusions (5% of blood volume) were compared: Ringer's lactate, serum albumin, and HES Pz (70% of the macromolecules between 100 000 and 1 000 000 d). When compared with Ringer's lactate and albumin, HES Pz significantly reduced the ratio of 24-hour infarct size to pretreatment area at risk (3% vs 19% and 16%, respectively) and myocardial water content (0.5% vs 3% and 1%). Potassium content differences between injured and normal myocardium were significantly less in the infarct regions of animals receiving HES Pz. In the canine model, HES Pz reduced 1-hour myocardial ischemia reperfusion injury significantly.

(Arch Surg. 1990;125:930-934)


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