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Differential Production of Interleukin 1 on the Surface of Biomaterials

Tyrone J. Krause, MD; Fredika M. Robertson, PhD; Janice B. Liesch, PhD; Arthur J. Wasserman, PhD; Ralph S. Greco, MD
Arch Surg. 1990;125(9):1158-1160. doi:10.1001/archsurg.1990.01410210084013.
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• The production of cytokines on the surface of surgical biomaterials plays a major role in their biocompatibility. Membraneassociated interleukin 1 (mlL-1) is a cytokine found on the surface of macrophages activated by biomaterials. To better understand the host—foreign body interaction, we quantitated the production of mlL-1 on the surface of two materials commonly used in surgery, expanded polytef (ePTFE) and silicon elastomer (SE). The mean (± SD) level of mlL-1 produced by adherent cells to ePTFE significantly decreased from day 2 (13746 ± 3630 cpm per disk) compared with day 7(2828 ± 1304 cpm per disk). However, the level of mlL-1 produced by ePTFE-adherent cells was still markedly greater than the level of mlL-1 produced by cells adherent to SE (1877±1028vs 1595 ±822 cpm per disk). These results indicate that ePTFE and SE elicit a differential host response in terms of cytokine production. This study may enhance our understanding of the cellular events on the surface of biomaterials that underlie clinical observations.

(Arch Surg. 1990;125:1158-1160)

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