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Article |

Reinforcement of Colonic Anastomoses With a Laser and Dye–Enhanced Fibrinogen

Nader Moazami; Mehmet C. Oz, MD; Lawrence S. Bass, MD; Michael R. Treat, MD
Arch Surg. 1990;125(11):1452-1454. doi:10.1001/archsurg.1990.01410230046008.
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• The incidence of anastomotic leakage in colonic surgery is approximately 10%. We evaluated a technique of laser-fibrinogen reinforcement to strengthen experimental colonic anastomoses. The technique consisted of the topical application of indocyanine green dye–enhanced fibrinogen to the serosal surface of two-layer inverting anastomoses, followed by exposure with an 808-nm diode laser. In the 28 rabbits used for this study, mean bursting pressure at time 0 was 108 ±13 mm Hg in the group receiving anastomoses with sutures alone and 173 ± 20 mm Hg in the group for which the sutured anastomosis was reinforced with laser-fibrinogen. The difference in bursting pressures between the two groups was statistically significant at time 0. However, at 1, 3, 5, and 7 days, the anastomosis became stronger in both groups and the difference in strength was reduced; the sutured group had more exceptionally weak (110 mm Hg) bonds than the group treated by laser. Thus, laser-fibrinogen reinforcement significantly enhances the early strength of sutured colonic anastomoses. This technique may reduce the incidence of leakage during the first postoperative week and the associated complications in a clinical setting.

(Arch Surg. 1990;125:1452-1454)


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