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Neuropeptide Y Inhibition of Vasoactive Intestinal Polypeptide–Stimulated Ion Transport in the Rabbit Distal Colon

J. Scott Flint, MD; Garth H. Ballantyne, MD; James R. Goldenring, MD, PhD; L. Peter Fielding, MD; Irvin M. Modlin, MD, PhD
Arch Surg. 1990;125(12):1561-1563. doi:10.1001/archsurg.1990.01410240039008.
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• We have studied the effect of neuropeptide Y on basal and vasoactive intestinal polypeptide–stimulated changes in the short-circuit current of strips of colonic mucosa from New Zealand white rabbits mounted in Ussing chambers. When administered to the basolateral surface, neuropeptide Y is found to decrease basal short-circuit current. Neuropeptide Y inhibits vasoactive intestinal peptide–stimulated increases in short-circuit current in a concentration-dependent fashion by a tetrodotoxin-insensitive mechanism. Also, neuropeptide Y inhibited increases in short-circuit current produced by direct stimulation of adenylate cyclase with forskolin. Furthermore, neuropeptide Y prevents vasoactive intestinal peptide–stimulated increases in tissue cyclic adenosine monophosphate levels. These results indicate that neuropeptide Y administered to the basolateral membrane inhibits vasoactive intestinal peptide–stimulated short-circuit current changes by a tetrodotoxin-insensitive mechanism that decreases tissue levels of cyclic adenosine 3′,5′-monophosphate.

(Arch Surg. 1990;125:1561 -1563)

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