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Macrophage Antigen Presentation and Interleukin 1 Production After Cecal Ligation and Puncture in C3H/HeN and C3H/HeJ Mice

Christopher C. Baker, MD; A. Tracy Niven-Fairchild; Alan Yamada, MD; Cheryl L. Caragnano; Thomas S. Kupper, MD
Arch Surg. 1991;126(2):253-258. doi:10.1001/archsurg.1991.01410260143021.
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• Following cecal ligation and puncture with a 25-gauge needle, endotoxin-sensitive C3H/HeN mice have a 45% mortality compared with no mortality in endotoxin-resistant C3H/HeJ mice. Macrophage production of interleukin 1 and antigen presentation were studied in these two strains of mice following cecal ligation and puncture at 2, 4, 8, 16, and 24 hours and at 2, 4, 6, and 8 days. Splenic macrophages were cultured with a T-helper cell clone (D10.G4.1), and antigen presentation and interleukin 1 production were measured by D10.G4.1 proliferation. Macrophage antigen presentation by C3H/HeJ mice was markedly increased compared with that in C3H/HeN mice at all times after cecal ligation and puncture, most strikingly at 2 days (185 740 cpm for C3H/HeJ mice vs 30 300 for C3H/HeN mice). Macrophage interleukin 1 production was significantly increased in C3H/HeJ mice vs C3H/HeN mice at all times after cecal ligation and puncture (except at 2 days) and was maximal at 8 days (25 000 cpm for C3H/HeJ mice vs 5190 for C3H/HeN mice). These data suggest that the differences in mortality after cecal ligation and puncture between these two strains of mice may relate to a supranormal response of macrophages of C3H/HeJ mice or to an inadequate response of macrophages of C3H/HeN mice.

(Arch Surg. 1991;126:253-258)

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