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Article |

Bacterial Translocation After Major Hepatectomy in Patients and Rats

Xiangdong Wang, MD; Roland Andersson, MD, PhD; Vasile Soltesz, MD, PhD; Stig Bengmark, MD, PhD
Arch Surg. 1992;127(9):1101-1106. doi:10.1001/archsurg.1992.01420090109016.
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• Bacterial infections are frequent complications after liver resection. Of 138 patients who underwent major hepatectomy, 11 patients (8%) developed intra-abdominal sepsis in the postoperative period. Seven bacterial strains of gut origin were isolated from the abdominal cavity. Eight patients had multiple bacteria cultured. In the experimental studies on rat models, positive mesenteric lymph node cultures were seen 2 hours after removal of 70% and 90% of the total weight of the rat liver, and 12 hours after 50% hepatectomy, persisting for 3 and 4 days after 50% and 70% hepatectomy, respectively. The incidences of bacteremia 2 and 4 hours after 90% hepatectomy were 80% and 100%, respectively; 6 hours after 70% liver resection, the incidence of bacteremia was 33%. Blood cultures were positive in only 6% of the rats following 50% hepatectomy, and in none of the controls. Thus, bacterial translocation occurs in the early course after hepatectomy, the incidence being proportional to the amount of liver tissue removed.

(Arch Surg. 1992:127:1101-1106)


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