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Article |

Administration of Dehydroepiandrosterone to Burned Mice Preserves Normal Immunologic Competence

Barbara A. Araneo, PhD; Jane Shelby, PhD; Gang-Zhou Li, MD; Wenwei Ku, MS; Raymond A. Daynes, PhD
Arch Surg. 1993;128(3):318-325. doi:10.1001/archsurg.1993.01420150074014.
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• Burned individuals display a reduced ability to elicit cellular and humoral immune responses and a depression in the in vitro production of certain T-cell lymphokines. Treatment of burned mice with 100 μg of dehydroepiandrosterone within 1 hour after injury resulted in preserving a completely normal capacity to produce T-cell—derived lymphokines and to generate cellular immune responses. In addition, dehydroepiandrosterone-treated thermally injured mice demonstrated an above-normal ability to resist an induced infection with the intracellular pathogen, Listeria monocytogenes. Dehydroepiandrosterone-treated animals also did not exhibit the sustained plasma levels of interleukin 6 that normally accompany thermal injury and infection. Because of its antiglucocorticoid effects and positive immunoregulatory influences, we believe dehydroepiandrosterone to be a beneficial form of therapy for thermally injured individuals.

(Arch Surg. 1993;128:318-325)


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