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Article |

Effects of Antimurine Interleukin-6 on Bacterial Translocation During Gut-Derived Sepsis

Roberto Gennari, MD; J. Wesley Alexander, MD, ScD; Tonyia Pyles; Sharon Hartmann; Cora K. Ogle, PhD
Arch Surg. 1994;129(11):1191-1197. doi:10.1001/archsurg.1994.01420350089012.
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Background:  Recent studies have shown that interleukin-6 (IL-6) is involved in the systemic changes that are associated with infection and tissue injury and that there is a correlation between high levels of IL-6 and poor outcome during several pathologic conditions.

Objective:  The effects of antimurine IL-6 antibody on survival and host defense were studied in a clinically relevant model of infection.

Methods:  Balb/c mice were treated with 10 μ of antimurine interleukin-6, a nonspecific mouse IgG, or placebo 1 hour before they underwent bacterial challenge by gavage of 1010Escherichia coli and burn injury. Survival and the extent of translocation of E coli were determined as well as the correlation between the IL-6 levels and survival times.

Results:  Survival after burn and gavage was 90% in animals treated with antimurine interleukin-6 vs 50% in animals treated with nonspecific IgG and 30% in salinetreated controls. A significant correlation between the levels of IL-6 and survival time was observed. Less translocation and better killing of bacteria were observed in the tissues of animals treated with antimurine interleukin-6.

Conclusions:  Interleukin-6 appears to play a major role in both the intensity of translocation of E coli from the intestine following burn injury and the host's ability to kill translocated organisms. Improved outcome was associated with a reduction of IL-6 levels by anti—IL-6 antibody.(Arch Surg. 1994;129:1191-1197)


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