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ARTICLE |

Efficacy of a Fibrin Hemostatic Bandage in Controlling Hemorrhage From Experimental Arterial Injuries

Michael J. Larson, VC; Jon C. Bowersox, MC; Robert C. Lim Jr, MC; John R. Hess, MC
Arch Surg. 1995;130(4):420-422. doi:10.1001/archsurg.1995.01430040082018.
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Objective:  To determine if a pressure dressing containing fibrinogen and thrombin could provide more effective control of arterial hemorrhage than a pressure dressing alone in an animal model of arterial injury.

Design:  Randomized acute (nonsurvival) experiment in swine.

Setting:  Federal biomedical research institute.

Animals:  Six anesthetized Yorkshire swine.

Interventions:  Uncontrolled arterial hemorrhage was induced in anesthetized swine by creating femoral artery lacerations. Hemorrhage was controlled by a gauze bandage containing fibrinogen and thrombin, applied with 1 minute of 3.5-kg pressure. The dressings were left in place for 1 hour after the pressure was removed. The contralateral limbs received identical treatment with plain gauze dressings.

Main Outcome Measures:  Total blood loss, mean arterial pressure, and mortality were measured after 1 hour.

Results:  After 1 hour, blood loss in the fibrin bandage group was 123±48 mL, compared with 734±134 mL in the control group (P=.0022). In the group treated with the fibrin bandages, there was no significant decrease in the mean arterial pressure after arterial laceration. In contrast, there was a decrease of 30 mm Hg in the group treated with gauze dressings alone. There was no animal mortality during the study period.

Conclusions:  Bandages containing fibrinogen and thrombin significantly reduced the amount of blood loss and allowed mean arterial pressures to be maintained in animals with uncontrolled hemorrhage from femoral artery lacerations. A hemostatic bandage may be an important adjuvant for controlling severe extremity hemorrhage in the prehospital setting.(Arch Surg. 1995;130:420-422)

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