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Familial Nonmedullary Thyroid Cancer An Emerging Entity That Warrants Aggressive Treatment

Richard F. Grossman, MD; Shih-Hsin Tu, MD; Quan-Yang Duh, MD; Allan E. Siperstein, MD; Faina Novosolov; Orlo H. Clark, MD
Arch Surg. 1995;130(8):892-899. doi:10.1001/archsurg.1995.01430080094015.
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Objective:  To determine whether familial nonmedullary thyroid carcinoma behaves like sporadic carcinoma of follicular cell origin.

Design:  Retrospective review.

Setting:  University medical center.

Patients:  Fourteen patients were treated for familial nonmedullary thyroid carcinoma between 1980 and 1994. Thirteen families were identified, with 30 affected individuals.

Interventions:  Patients were treated with total or completion total thyroidectomy. Thirteen additional operations were performed to control recurrent disease.

Main Outcome Measures:  Stage, recurrence, and survival. Patients were followed up for a mean of 6.5 years.

Results:  In our 14 patients, 13 tumors were multifocal, and six of these were bilateral. The incidences of lymph node metastasis and local invasion were both 57% (n=8). Seven patients (50%) had recurrences during follow-up.

Conclusions:  Familial nonmedullary thyroid carcinoma has a high incidence of multifocality and invasion and a high rate of local recurrence. Aggressive initial treatment and careful follow-up seem to be indicated.(Arch Surg. 1995;130:892-899)


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