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Isolated Limb Perfusion of an Irradiated Foot With Tumor Necrosis Factor, Interferon, and Melphalan

Robert J. van Ginkel, MD; Harald J. Hoekstra, MD, PhD; Alex M. M. Eggermont, MD, PhD; Elisabeth Pras, MD; Heimen Schraffordt Koops, MD, PhD
Arch Surg. 1996;131(6):672-674. doi:10.1001/archsurg.1996.01430180098022.
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A 57-year-old woman presented with the second recurrence of a high-grade malignant fibrous histiocytoma of the right foot, following previous local resection plus curative adjuvant radiotherapy. The first recurrence of the lesion was treated by isolated limb perfusion with cisplatin; the second recurrence was treated by isolated limb perfusion with tumor necrosis factor, interferon, and melphalan. The tumor and the area that had been irradiated showed a bluish color a few hours after tumor necrosis factor perfusion. Amputation of the right foot and leg below the knee had to be performed because of severe necrosis. (Arch Surg. 1996;131:672-674)


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