Preresection Chemotherapy Improves Survival for Children With Askin Tumors

Robert S. Sawin, MD; Ernst U. Conrad III, MD; Julie R. Park, MD; John H. T. Waldhausen, MD
Arch Surg. 1996;131(8):877-880. doi:10.1001/archsurg.1996.01430200087015.
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Objective:  To test whether patients with Askin tumor treated with aggressive neoadjuvant chemotherapy have a better clinical outcome.

Design:  Retrospective case series.

Setting:  Pediatric referral center.

Patients:  All children diagnosed with malignant small-cell tumors of the chest wall (Askin tumor) and treated from 1975 to September 1987 (phase 1, n=6) and from September 1987 to the present (phase 2, n=9).

Main Outcome Measures:  Survival as a function of extent of disease and response to therapy as measured by tumor volume, survival, and recurrence.

Results:  All phase 2 patients had significant reduction of tumor volume and improved survival by Kaplan-Meier estimates compared with phase 1 patients. No phase 1 patients are still alive.

Conclusion:  Patients with Askin tumor treated with aggressive preresection chemotherapy have smaller tumors to resect and improved survival.Arch Surg. 1996;131:877-880


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