The application of cryosurgery for in situ freezing and subsequent devitalization of neoplastic lesions have been successful in cancers of the prostate and the liver. In the phase 1 to 3 in vivo analyses published in this issue of the Archives, Staren and associates confirm the facilitation and reproducibility of ultrasound-monitored cryoablation of carcinogen-induced mammary adenocarcinoma in Sprague-Dawley rats. This research group completed a human trial of 2 invasive lobular carcinomas using the same technology; core-needle biopsy 4 and 6 weeks subsequently confirmed the absence of persistent tumor.
This study confirms the potential application of an evolving technology to early-stage breast carcinoma, as this therapeutic approach allows the maintenance of optimal cosmesis with use of a technique that is atraumatic and presumably costeffective. The advantages of cryodestruction of small breast neoplasms are well described and documented by the investigators. This analysis confirms that lesions 1.5 cm or larger were incompletely