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Growth Hormone Attenuates the Acute-Phase Response to Thermal Injury

Doraid Jarrar, MD; Steven E. Wolf, MD; Marc G. Jeschke, MD; Roque J. Ramirez, MD; Meelie DebRoy, MD; Cora K. Ogle, PhD; John Papaconstaninou, PhD; David N. Herndon, MD
Arch Surg. 1997;132(11):1171-1176. doi:10.1001/archsurg.1997.01430350021003.
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Objective:  To determine the effects of growth hormone (GH) on the hepatic acute-phase response (APR) in a burned rat model.

Setting:  Laboratory.

Material:  Male Sprague-Dawley rats (weight, 300-350 g).

Interventions:  Rats underwent a 40% total body surface area burn injury and received GH or saline solution daily by subcutaneous injection. Unburned rats served as controls.

Main Outcome Measures:  Hepatic messenger RNA (mRNA) expression and serum levels of α1-acid glycoprotein and albumin were determined 2, 7, and 14 days after injury.

Results:  The serum α1-acid glycoprotein levels in GH-treated animals did not increase on days 2 and 7, whereas saline-treated animals showed a major increase. Hepatic mRNA expression increased dramatically on day 2 for burned groups; however, the mRNA pool levels of GH-treated animals showed a faster rate of decline to control levels on days 7 and 14. The albumin mRNA pool levels of GH-treated and control animals did not show significant differences, whereas the negative APR, indicated by loss of albumin mRNA, was more pronounced on day 7 in the saline-treated animals. By day 14, mRNA levels were comparable in all 3 groups.

Conclusion:  Growth hormone attenuated the positive APR, as indicated by a decrease in α1-acid glycoprotein expression and production, and prevented the negative APR, as seen by an absence of a decline of albumin mRNA pool levels and serum concentration. We conclude that the beneficial effects of GH on thermal injury may be due in part to a modification of the APR.Arch Surg. 1997;132:1171-1175


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