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January 1976, Vol 111, No. 1 >
ARTICLE | January 1976

Growth of Baby Kidneys Transplanted Into Adults FREE

Sherman J. Silber, MD
[+] Author Affiliations

Accepted for publication May 28, 1975.

Reprint requests to Veterans Administration Hospital, 4150 Clement St, San Francisco, CA 94121 (Dr Silber).


Arch Surg. 1976;111(1):75-77. doi:10.1001/archsurg.1976.01360190077014
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• To determine whether the growth of a kidney is affected by the age of the host or is independently programmed, baby rat kidneys were isologously transplanted into adult rats that underwent unilateral or bilateral nephrectomies. The growth of these transplanted baby kidneys was compared to the growth of baby kidneys that were left intact in the growing baby rat. After allowing for compensatory hypertrophy, the kidneys, whether in babies or adults, were found to grow at the same rate and to the same ultimate size. Renal size could be predictably related to renal age, but not to the age of the host.

(Arch Surg 111:75-77, 1976)

REFERENCES

1 +
Silber S, Malvin R:  Compensatory and obligatory renal growth in rats . Am J Physiol 226:114-117, 1974;.
2 +
Silber S, Crudup J:  The three-kidney rat model . Invest Urol 11:466-470, 1974;.
3 +
Silber S:  Compensatory and obligatory renal growth in babies and adults . Aust NZ J Surg 44:421-423, 1974;.
4 +
Klein TW, Gittes RF:  The three-kidney rat: Renal isografts and renal counterbalance . J Urol 109:19-27, 1973;.
5 +
Silber S, Crudup J:  Kidney transplantation in inbred rats . Am J Surg 125:551-553, 1973;.
6 +
Shanks SC, Kerley P (eds): A Textbook of X-ray Diagnosis by British Authors in Six Volumes , ed 2. Philadelphia, WB Saunders Co, 1970;, vol 5, p 302.
7 +
McCreight CE, Sulkin NM:  Cellular proliferation in the kidneys of young and senile rats following unilateral nephrectomy . J Gerontol 14:440-443, 1956;.
8 +
MacKay EM, MacKay LL, Addis T:  The degree of compensatory renal hypertrophy following unilateral nephrectomy: I. The influence of age . J Exp Med 56:255-265, 1932;.
9 +
Barrows CH Jr, Roeder LM, Olewine DA:  The effect of age on renal compensatory hypertrophy following unilateral nephrectomy in the rat . J Gerontol 17:148-150, 1962;.
10 +
Pepper FJ: Transplantation of thymic tissue in the inbred strains of mice. J Endocrinol 22:349-359, 1961;.
11 +
Metcalf D:  The autonomous behavior of normal thymus grafts . Aust J Exp Biol Med Sci 41:437-447, 1963;.
12 +
Metcalf D:  The thymus and lymphopoeisis , in Good RA, Gabrielsen AE (eds): The Thymus in Immunobiology . New York, Hoeber-Harper, 1964;, p 150.
13 +
Silber S:  Renal transplantation between adults and children: Differences in renal growth . JAMA 228:1143-1145, 1974;.
14 +
Silber S:  Extra renal function in patients with duplication anomaly: Obligatory and compensatory renal growth . J Urol 112:423-424, 1974;.
15 +
Kaufman JM, Di Meola HJ, Siegel NJ, et al:  Compensatory adaptation of structure and function following progressive renal ablation . Kidney Int 6:10-17, 1974;.

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1 +
Silber S, Malvin R:  Compensatory and obligatory renal growth in rats . Am J Physiol 226:114-117, 1974;.
2 +
Silber S, Crudup J:  The three-kidney rat model . Invest Urol 11:466-470, 1974;.
3 +
Silber S:  Compensatory and obligatory renal growth in babies and adults . Aust NZ J Surg 44:421-423, 1974;.
4 +
Klein TW, Gittes RF:  The three-kidney rat: Renal isografts and renal counterbalance . J Urol 109:19-27, 1973;.
5 +
Silber S, Crudup J:  Kidney transplantation in inbred rats . Am J Surg 125:551-553, 1973;.
6 +
Shanks SC, Kerley P (eds): A Textbook of X-ray Diagnosis by British Authors in Six Volumes , ed 2. Philadelphia, WB Saunders Co, 1970;, vol 5, p 302.
7 +
McCreight CE, Sulkin NM:  Cellular proliferation in the kidneys of young and senile rats following unilateral nephrectomy . J Gerontol 14:440-443, 1956;.
8 +
MacKay EM, MacKay LL, Addis T:  The degree of compensatory renal hypertrophy following unilateral nephrectomy: I. The influence of age . J Exp Med 56:255-265, 1932;.
9 +
Barrows CH Jr, Roeder LM, Olewine DA:  The effect of age on renal compensatory hypertrophy following unilateral nephrectomy in the rat . J Gerontol 17:148-150, 1962;.
10 +
Pepper FJ: Transplantation of thymic tissue in the inbred strains of mice. J Endocrinol 22:349-359, 1961;.
11 +
Metcalf D:  The autonomous behavior of normal thymus grafts . Aust J Exp Biol Med Sci 41:437-447, 1963;.
12 +
Metcalf D:  The thymus and lymphopoeisis , in Good RA, Gabrielsen AE (eds): The Thymus in Immunobiology . New York, Hoeber-Harper, 1964;, p 150.
13 +
Silber S:  Renal transplantation between adults and children: Differences in renal growth . JAMA 228:1143-1145, 1974;.
14 +
Silber S:  Extra renal function in patients with duplication anomaly: Obligatory and compensatory renal growth . J Urol 112:423-424, 1974;.
15 +
Kaufman JM, Di Meola HJ, Siegel NJ, et al:  Compensatory adaptation of structure and function following progressive renal ablation . Kidney Int 6:10-17, 1974;.

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