A Comparison of the Use of Cephalothin and Oxacillin in Vascular Surgery FREE

Andrew R. L. May, FRCS; R. Clement Darling, MD; David C. Brewster, MD; Cynthia S. Darling, RN, MS

[+] Author Affiliations

Accepted for publication April 11, 1979.

Reprint requests to 3 Hawthorne PI, Boston, MA 02114 (Dr Darling).

Arch Surg. 1980;115(1):56-59. doi:10.1001/archsurg.1980.01380010048009

Text Size: A A A

Published online

Article

References

Comments

ABSTRACT

ABSTRACT | REFERENCES

• A randomized trial comparing two prophylactic antibiotics in vascular surgery was reviewed retrospectively. Two hundred thirty-two patients were given cephalothin sodium, and 168 patients were given oxacillin sodium. The overall incidence of wound infection was 1.5%; there was only one prosthetic graft infection in 346 patients in whom prosthetic material was used. There was no significant difference in wound infection between the groups. When postoperative infection in other areas was considered, however, it appeared that cephalothin was a more suitable antibiotic for treatment of these infections despite its use prophylactically. Although this trial was uncontrolled, the low overall incidence of wound and graft infection would appear to support the use of prophylactic antibiotics in vascular surgery.

(Arch Surg 115:56-59, 1980)

REFERENCES

ABSTRACT | REFERENCES

Goldstone J, Moore WS: Infection in vascular prostheses . Am J Surg 128:225-233, 1974;.

Szilagyi DE, Smith RF, Elliott JP, et al: Infection in arterial reconstruction with synthetic grafts . Am Surg 176:321-333, 1972;.

Fry WJ, Lindenauer SM: Infections complicating the use of plastic arterialimplants . Arch Surg 94:600-608, 1967;.

Hoffert PW, Gensler S, Haimovici H: Infection complicating arterial grafts . Arch Surg 90:427-435, 1965;.

Lindenauer SM, Fry WJ, Schaub G, et al: Use of antibiotics in the prevention of vascular graft infections . Surgery 62:487-492, 1967;.

Moore WS, Rosson CT, Hall AD: Effect of prophylactic antibiotics in preventing bacteraemic infection in vascular prostheses . Surgery 69:825-828, 1971;.

Gordon-Smith IC, Taylor EW, Nicolaides AN, et al: Management of abdominal aortic aneurysm . Br J Surg 65:834-838, 1978;.

Kaiser AB, Clayson KR, Mulherin J, et al: Antibiotic prophylaxis in vascular surgery . Ann Surg 188:283-289, 1978;.

Burke JF: Preoperative antibiotics . Surg Clin North Am 43:665-676, 1963;.

Linton RR: The prophylactic use of antibiotics in clean surgery . Surg Gynecol Obstet 112:218-220, 1961;.

Polk HC, Lopez-Mayor JF: Postoperative wound infection: A prospective study of determinant factors and prevention . Surgery 66:97-103, 1969;.

Alexander JS, Sykes NS, Mitchell MM, et al: Concentration of selected intravenously administered antibiotics in experimental surgical wounds . J Trauma 13:432-434, 1973;.

Moore WS, Rosson CT, Hall AD, et al: Transient bacteraemia: A cause of infection in prosthetic vascular grafts . Am J Surg 117:342-343, 1969;.

Madharan T, Quinn EL, Freimer E: Clinical studies of cefazolin and comparison with other cephalosporins . Antimicrob Agents Chemother 4:525-531, 1973;.

Goldman DA, Hopkins CC, Karchmer AW, et al: Cephalothin prophylaxis in cardiac valve surgery: A prospective double-blind comparison of two-day and six-day regimens . J Thorac Cardiovasc Surg 73:470-479, 1977;.

Lennihan R Jr: Prophylactic antibiotics in arterial surgery: A personal experience covering 218 operations . Del Med J 45:31-35, 1973;.

Moore WS, Cafferata HT, Hall AD, et al: In defense of grafts across the inguinal ligament . Ann Surg 168:207-214, 1968;.

Wise R: Use of antibiotics: Cephalosporins . Br Med J 2:40-42, 1978;.

First Page Preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal