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August 1981, Vol 116, No. 8 >
ARTICLE | August 1981

Effective Streptozocin Therapy for Metastatic Pancreatic Polypeptide Apudoma FREE

Stanley R. Friesen, MD, PhD; Ronald L. Stephens, MD; G. Stedman Huard, II, MD
[+] Author Affiliations

Accepted for publication Feb 27, 1981.

Reprint requests to Department of Surgery, University of Kansas Medical Center, 39th and Rainbow Boulevard, Kansas City, KS 66103 (Dr Friesen).


Arch Surg. 1981;116(8):1090-1092. doi:10.1001/archsurg.1981.01380200086019
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References
Comments

• An apparently complete remission of metastases in the liver from a resected pure pancreatic polypeptide apudoma occurred following intra-arterial and intravenous administration of streptozocin to a patient in a family with multiple endocrine adenopathy, type 1. Plasma concentrations of human pancreatic polypeptide constitute an excellent marker system for the detection and assessment of tumor status before and after surgical and streptozocin therapy.

(Arch Surg 1981;116:1090-1092)

REFERENCES

1 +
Murray-Lyon IM, Eddleston ALWF, William R, et al:  Treatment of Multiple-hormone producing malignant islet cell tumor with streptozotocin . Lancet 1968;;2:895-898.
2 +
Broder LE, Carter SK:  Pancreatic islet cell carcinoma: Results of therapy with streptozotocin in 52 patients . Ann Intern Med 1973;;79:108-118.
3 +
Stadil F, Stage G, Rehfeld JF, et al:  Treatment of Zollinger-Ellison syndrome with streptozotocin . N Engl J Med 1976;;294:1440-1442.
4 +
Schein P, Kahn R, Gorden P, et al:  Streptozotocin for malignant insulinomas and carcinoid tumor: Report of eight cases and review of the literature . Arch Intern Med 1973;;132:555-561.
5 +
Gagel RF, Costanza ME, DeLellis RA, et al:  Streptozocin-treated Verner-Morrison syndrome: Plasma vasoactive intestinal peptide and tumor responses . Arch Intern Med 1976;;136:1429-1435.
6 +
Danforth DN Jr, Triche T, Doppman JL, et al:  Elevated plasma proglucagon-like component with a glucagon-secreting tumor: Effect of streptozotocin . N Engl J Med 1976;;297:242-245.
7 +
Oberg K, Bostrom H, Fahrenkrug J, et al:  Streptozotocin treatment of a pancreatic tumor producing VIP and gastrin associated with Verner-Morrison syndrome . Acta Med Scand 1979;;206:223-227.
8 +
Kahn RC, Levy AG, Gargerner JD, et al:  Pancreatic cholera: Beneficial effects of treatment with streptozotocin . N Engl J Med 1975;;292:941-945.
9 +
Pipelers D, Somers G, Gepts W, et al:  Plasma pancreatic hormone levels in a case of somatostatinoma: Diagnostic and therapeutic implications . J Clin Endocrinol Metab 1979;;49:572-579.
10 +
DeWys WD, Stoll R, Au WY, et al:  Effects of streptozotocin on an islet cell carcinoma with hypercalcemia . Am J Med 1973;;55:671-676.
11 +
Pitkin RM, Reynolds WA:  Diabetogenic effects of streptozotocin in rhesus monkeys . Diabetes 1979;;19:85-90.
12 +
Kimmel JR, Hayden LJ, Pollock HG:  Isolation and characterization of a new pancreatic polypeptide hormone . J Biol Chem 1975;;250:9369-9376.
13 +
Lin TM, Chance RE:  Gastrointestinal actions of a new bovine pancreatic polypeptide (BPP) , in Chey WY, Brooks FP (eds): Endocrinology of the Gut . Thorofare, NJ, Charles B Slack Inc, 1974;, pp 143-145.
14 +
Floyd JC Jr, Fajans SS, Pek S, et al:  A newly recognized pancreatic polypeptide: Plasma levels in health and disease . Recent Prog Horm Res 1977;;33:519-570.
15 +
Friesen SR, Kimmel JR, Tomita T:  Pancreatic polypeptide as screening marker for pancreatic polypeptide apudomas in multiple endocrinopathies . Am J Surg 1980;;139:61-72.
16 +
Friesen SR:  The development of endocrinopathies in the prospective screening of two families with multiple endocrine adenopathy, type World J Surg 1979;;3:753-764.

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1 +
Murray-Lyon IM, Eddleston ALWF, William R, et al:  Treatment of Multiple-hormone producing malignant islet cell tumor with streptozotocin . Lancet 1968;;2:895-898.
2 +
Broder LE, Carter SK:  Pancreatic islet cell carcinoma: Results of therapy with streptozotocin in 52 patients . Ann Intern Med 1973;;79:108-118.
3 +
Stadil F, Stage G, Rehfeld JF, et al:  Treatment of Zollinger-Ellison syndrome with streptozotocin . N Engl J Med 1976;;294:1440-1442.
4 +
Schein P, Kahn R, Gorden P, et al:  Streptozotocin for malignant insulinomas and carcinoid tumor: Report of eight cases and review of the literature . Arch Intern Med 1973;;132:555-561.
5 +
Gagel RF, Costanza ME, DeLellis RA, et al:  Streptozocin-treated Verner-Morrison syndrome: Plasma vasoactive intestinal peptide and tumor responses . Arch Intern Med 1976;;136:1429-1435.
6 +
Danforth DN Jr, Triche T, Doppman JL, et al:  Elevated plasma proglucagon-like component with a glucagon-secreting tumor: Effect of streptozotocin . N Engl J Med 1976;;297:242-245.
7 +
Oberg K, Bostrom H, Fahrenkrug J, et al:  Streptozotocin treatment of a pancreatic tumor producing VIP and gastrin associated with Verner-Morrison syndrome . Acta Med Scand 1979;;206:223-227.
8 +
Kahn RC, Levy AG, Gargerner JD, et al:  Pancreatic cholera: Beneficial effects of treatment with streptozotocin . N Engl J Med 1975;;292:941-945.
9 +
Pipelers D, Somers G, Gepts W, et al:  Plasma pancreatic hormone levels in a case of somatostatinoma: Diagnostic and therapeutic implications . J Clin Endocrinol Metab 1979;;49:572-579.
10 +
DeWys WD, Stoll R, Au WY, et al:  Effects of streptozotocin on an islet cell carcinoma with hypercalcemia . Am J Med 1973;;55:671-676.
11 +
Pitkin RM, Reynolds WA:  Diabetogenic effects of streptozotocin in rhesus monkeys . Diabetes 1979;;19:85-90.
12 +
Kimmel JR, Hayden LJ, Pollock HG:  Isolation and characterization of a new pancreatic polypeptide hormone . J Biol Chem 1975;;250:9369-9376.
13 +
Lin TM, Chance RE:  Gastrointestinal actions of a new bovine pancreatic polypeptide (BPP) , in Chey WY, Brooks FP (eds): Endocrinology of the Gut . Thorofare, NJ, Charles B Slack Inc, 1974;, pp 143-145.
14 +
Floyd JC Jr, Fajans SS, Pek S, et al:  A newly recognized pancreatic polypeptide: Plasma levels in health and disease . Recent Prog Horm Res 1977;;33:519-570.
15 +
Friesen SR, Kimmel JR, Tomita T:  Pancreatic polypeptide as screening marker for pancreatic polypeptide apudomas in multiple endocrinopathies . Am J Surg 1980;;139:61-72.
16 +
Friesen SR:  The development of endocrinopathies in the prospective screening of two families with multiple endocrine adenopathy, type World J Surg 1979;;3:753-764.

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