RT Journal A1 Bickel A, Eitan A T1 SUpplemental oxygen and surgical site infection—reply JF Archives of Surgery JO Archives of Surgery YR 2011 FD October 1 VO 146 IS 10 SP 1221 OP 1223 DO 10.1001/archsurg.2011.291 UL http://dx.doi.org/10.1001/archsurg.2011.291 AB The issue of hyperoxygenation and wound site infection is controversial and well discussed in the medical literature. The reasons for a surgical site infection are multifactorial, and the data interpretation can be affected by many factors. Our aim was to further illuminate the subject by choosing to study as homogenous as possible a population of patients with a surgical site infection associated with the right lower incision for acute appendicitis. In light of our introduction and expanded Comment section, we cannot ignore feeling that Dr Sessler's comments regarding the hypothesis and our clinical trial's registration are somehow surprising and “curious.”