RT Journal
A1 Cocieru A, Saldinger PF
T1 SUrgical management of the succinate dehydrogenase–associated familial paraganglioma syndromes
JF Archives of Surgery
JO Archives of Surgery
YR 2012
FD January 1
VO 147
IS 1
SP 89
OP 91
DO 10.1001/archsurg.2011.552
UL http://dx.doi.org/10.1001/archsurg.2011.552
AB Paragangliomas are rare neuroendocrine tumors arising from the neural crest cells in the extra-adrenal location. Paragangliomas can be sporadic or associated with a range of endocrine and genetic syndromes in 25% to 30% of all cases. Specifically, succinate dehydrogenase gene mutations are involved in the development of paraganglioma syndromes type 1 through type 4. In this article, we will describe 2 cases of succinate dehydrogenase–associated familial paraganglioma syndrome and provide a review of the existing literature on the condition's etiologic factors, diagnosis, and management.