RT Journal
A1 Katz MG, Hu C, Fleming JB, Pisters PT, Lee JE, Chang GJ
T1 CLinical calculator of conditional survival estimates for resected and unresected survivors of pancreatic cancer
JF Archives of Surgery
JO Archives of Surgery
YR 2012
FD June 1
VO 147
IS 6
SP 513
OP 519
DO 10.1001/archsurg.2011.2281
UL http://dx.doi.org/10.1001/archsurg.2011.2281
AB Objective 
                  To calculate conditional survival estimates for patients with pancreatic adenocarcinoma.Design 
                  We constructed separate multivariate survival models adjusted for 7 clinicopathologic factors for patients who did and did not undergo radical surgical resection.Participants 
                  Patients with pancreatic adenocarcinoma diagnosed between 1988 and 2005 included in the Surveillance Epidemiology End Results cancer registry.Main Outcome Measure 
                  Internet browser–based calculator to compute personalized survival estimates.Results 
                  Conditional survival probabilities increased over time for all patients with pancreatic cancer regardless of patient characteristics, disease stage, or treatment. For patients with resected stage I, II, or III disease, 3-year conditional cancer-specific survival increased from 38% to 70%, 19% to 54%, and 8% to 39%, respectively, over the 3 years following diagnosis. The relative improvement in survival over time was larger for patients with advanced disease. A customizable, Internet browser-based clinical calculator was implemented that may be used to compute in real time personalized conditional survival estimates based on an individual's unique clinicopathologic profile.Conclusions 
                  Conditional survival estimates provide a more accurate—and typically more optimistic—assessment of prognosis for patients with pancreatic cancer than traditional survival estimates that apply only at the initial diagnosis.