RT Journal A1 Baue AE T1 Systemic inflammatory response syndrome and magic bullets: Finding the target and improving the aim—reply JF Archives of Surgery JO Archives of Surgery YR 1998 FD March 1 VO 133 IS 3 SP 334 OP 335 DO UL http://dx.doi.org/ AB Dr Zikria and colleagues, in a book titled Reperfusion Injuries and Capillary Leak Syndrome,1 attribute the increased capillary permeability after injury to reperfusion injury and/or inflammation. Certainly, many sick patients retain fluid and have interstitial edema as they progress from SIRS to multiple organ dysfunction syndrome to multiple organ failure. This is an unsolved and difficult clinical abnormality.