RT Journal
A1 Saxe A
T1 Invited critique: Pathologic features of prognostic significance for adrenocortical carcinoma after curative resection
JF Archives of Surgery
JO Archives of Surgery
YR 1999
FD February 1
VO 134
IS 2
SP 185
OP 185
DO 10.1001/archsurg.134.2.185
UL http://dx.doi.org/10.1001/archsurg.134.2.185
AB 
Harrison et al have built on Brennan's long-standing interest in adrenocortical carcinoma, using the Memorial Sloan-Kettering Cancer Center's extensive experience and detailed database to compile a unique report. This series correlates histologic features of resected tumors with clinical outcome, but only in patients undergoing curative surgery. As they properly point out, other investigators have made the same correlation, but not in reports restricted to patients treated with curative surgery. Series "contaminated" by patients undergoing palliative surgery who received adjuvant therapy may obscure more subtle findings that should more properly influence the use of adjuvant therapy. Some may argue that the issue is moot without effective adjuvant agents. Although mitotane has been almost uniformly disappointing, there is hope that taxanes may be effective.